CpG receptors

Promoter CpG methylation of oestrogen receptors in leukaemia.

Previous studies have suggested an important role of ERs (oestrogen receptors) in the pathogenesis of leukaemias. However, there is no information so far about the epigenetic characteristics of ERalpha isoforms and ERbeta in leukaemias. In the present study, the mRNA expression and promoter CpG methylation of ERalpha isoforms (i.e. ERalpha-A, -B and -C) and ERbeta in leukaemia cell lines were e...

CpG and Non-CpG Oligodeoxynucleotides

Identified serotonergic neurons in the Tritonia swim CPG activate both ionotropic and metabotropic receptors.

Although G-protein-coupled (metabotropic) receptors are known to modulate the production of motor patterns, evidence from the escape swim central pattern generator (CPG) of the nudibranch mollusk, Tritonia diomedea, suggests that they might also participate in the generation of the motor pattern itself. The dorsal swim interneurons (DSIs), identified serotonergic neurons intrinsic to the Triton...

Suppressive CpG

Cellular constipation can be deadly, according to a study on page 1587. Wang and colleagues show that cells get clogged with aborted secretory cargo when they lack an enzyme that helps form vesicles. Deletion of this enzyme proved lethal in mice, halting brain, bone and vascular development. The enzyme in question is a protein tyrosine phosphatase (PTP) called MEG2. MEG2 binds lipids and reside...

CpG underrepresentation and the bacterial CpG-specific DNA methyltransferase M.MpeI.

Cytosine methylation promotes deamination. In eukaryotes, CpG methylation is thought to account for CpG underrepresentation. Whether scarcity of CpGs in prokaryotic genomes is diagnostic for methylation is not clear. Here, we report that Mycoplasms tend to be CpG depleted and to harbor a family of constitutively expressed or phase variable CpG-specific DNA methyltransferases. The very CpG poor ...